Glutathione trapping of reactive drug metabolites produced by biomimetic metalloporphyrin catalysts
نویسندگان
چکیده
منابع مشابه
Shape Selective Alkane Hydroxylation by Metalloporphyrin Catalysts+
A series of manganese and iron porphyrins with sterically protected pockets are shown to be shape selective alkane hydroxylation catalysts. With iodosobenzene as oxidant, good regioselectivity is observed for hydroxylation of alkanes at the least hindered methyl group by using the very sterically hindered (5,10,15,20-tetrakis(2’,4’,6’-triphenylphenyl)porphyrinato)manganese(III) acetate (MnTTPPP...
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In nature, metalloporphyrins are well known for performing many biological functions in aqueous media, such as light harvesting, oxygen transportation, and catalysis. Heme, the iron–porphyrin derivative, is the cofactor for many enzyme/ protein families, including peroxidases, cytochromes, hemoglobins, and myoglobins. Using synthetic systems to mimic natural enzymes with high catalytic activity...
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Drug Metabolism and Pharmacokinetics Research Laboratories (S.N., H.T., A.W., Y.M., W.S., D.S., T.I.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan Clinical Data and Biostatistics Department (K.S., K.H.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromachi, Shinagawa-ku, Tokyo, 140-8710, Japan R&D Planning Department (O.O.), Daiichi Sankyo Co., Ltd., 1-2-58, Hiromac...
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ژورنال
عنوان ژورنال: Rapid Communications in Mass Spectrometry
سال: 2015
ISSN: 0951-4198
DOI: 10.1002/rcm.7290